A combination of LCPUFA ameliorates airway inflammation in asthmatic mice by promoting pro-resolving effects and reducing adverse effects of EPA.

Compared with healthy mice, sensitization with HDM led to a highly significant increase in total immune cell numbers of asthmatic mice (PBS: 0.18 ± 0.05 × 10 6 cells/mL; HDM: 1.34 ± 0.16 × 10 6 cells/mL, p < 0.001) with eosinophils from 0.00 ± 0.00% to 57.45 ± 1.84% ( p < 0.001).

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Furthermore, we examined IL-6 which was diminished significantly by the LCPUFA combination, but almost significantly increased by EPA supplementation compared with LCPUFA-supplemented mice (Fig. 1d : IL-6: PBS: 93.25 ± 8.84 fg/mL, p < 0.001; HDM: 68791.00 ± 17601.00 fg/mL, LCPUFA: 27212.00 ± 7621.00 fg/mL, p < 0.05; EPA: 78843.00 ± 27842.00 fg/mL, p = 0.09).

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4c ) were increased highly significant by EPA ( p < 0.01) and almost significant by the sc-LCPUFA blend ( p = 0.05).

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