However, similar to the sIPSC recording, mIPSC frequency showed a decreasing trend in the Oga +/− condition, which was rescued to a control level by OGA overexpression (Supplementary Fig.
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Elevated O-GlcNAcylation induces an antidepressant-like phenotype and decreased inhibitory transmission in medial prefrontal cortex.
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The immobility time in the TST also showed an increasing trend in Oga +/− mice when OGA was overexpressed in the mPFC (Fig. 4C ).