The reduction in the CFUs recovered from lungs of the aP- aP-, aP- OMV P-, and aP-wP–immunized mice ranged from 2.9 to 3.6 orders of magnitude (non-significant differences between those treatments) in comparison to the highly significant difference relative to non-immunized animals ( p < 0.001).
In humans, extremely significant data recently obtained would support the following statements: (1) human maternal immunization is safe for women and fetuses, (2) maternal-immunization strategy is able to decrease the lethality rates in newborns and infants born to immunized mothers ( Fabricius et al., 2018 ; Gentile et al., 2018 ) and (3) maternal immunization is highly protective against pertussis, especially in the first 2 months of life, but also up to the first year.