High cytomegalovirus serology and subsequent COPD-related mortality: a longitudinal study.

After adjusting for sex, age, body mass index (BMI), level of education, smoking status and pack-years, subjects in the highest tertile for CMV serology (hereafter referred to as high CMV serology) had a 21% increase in all-cause mortality risk compared to subjects in the lowest tertile, although the association was of borderline significance ( table 2 and figure 1a ).

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However, there was a highly significant CMV-by-age interaction, indicating that the relation of CMV serology to mortality decreased as age at enrolment increased (p-value for interaction <0.001), with significant effects of CMV on all-cause mortality up to ∼55 years of age at enrolment ( figure 2 ).

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