Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease.

Aging (Albany NY) · 2020 · PMC7185133 · PMID 32255762

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a small trendno p-value reported

We observed a small trend toward reduction of macrophages infiltration by norbixin, however this was not statistically significant (data not shown).

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