a decreasing trendp >0.05
In general, a dose-dependent increase in the production of cytokines was observed with RR1 except for IL-12 p40 which recorded the maximum at 10 μg/ml ( p <0.05) and further increase in the RR1 exhibited a decreasing trend with no significant difference between 50 μg and 100 μg/ml concentrations ( p >0.05).