Animal Disease Surveillance in the 21st Century: Applications and Robustness of Phylodynamic Methods in Recent U.S. Human-Like H3 Swine Influenza Outbreaks.

Although Iowa and Minnesota are the original hotspots of H3 viruses, our BSSVS BF results showed a markedly significant viral dispersal route between Indiana and Ohio (BF = 990) ( Figure 7H ).

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Nevertheless, using the PB2 segment, a highly significant dispersal route was inferred from Iowa to Minnesota, suggesting that Iowa might be the new epicenter for virus dispersal of the currently circulating H3 lineages ( Figure 8D ).

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