Chaperone co-inducer BGP-15 mitigates early contractile dysfunction of the soleus muscle in a rat ICU model.

Although a slight trend of atrophy and myosin loss being more prominent in slow‐ than fast‐twitch muscles and interpreted to be secondary to a faster protein turnover rate in slow‐ than fast‐twitch muscles. 9 However, the mechanisms underlying the impaired force generation capacity (specific force) at the single muscle fibre level differ between limb and diaphragm muscles, although the molecular motor protein myosin plays a critical role in both limb and respiratory muscles.

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