Histone ChIP-Seq identifies differential enhancer usage during chondrogenesis as critical for defining cell-type specificity.

Fewer than 2% of total CpGs probes present on the Infinium HumanMethylation450K BeadChip were located within chondrocyte chromatin state 13_EnhS (strong enhancers) yet remarkably 41.8% of de‐methylated CpGs were found in this chromatin state (Figure 5 E), a highly significant over‐representation (Chi‐square test P < .001).

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