Increased insulin receptor binding and increased IGF-1 receptor binding are linked with increased growth of L6hIR cell xenografts in vivo.

Change in bodyweight, but not epididymal fat mass, had a significant effect on xenograft mass (P = 0.0069), but the effect of treatment was still highly significant (P < 0.0001) and the differences between groups treated with vehicle, HI or IX10 were fully comparable to the effects observed when the effect of bodyweight was not included in the analysis (Supplementary Table S4 ).

also in 132,142 other papers