Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation.

Only highly enriched (enrichment over background ≥5-fold, pileup ≥25) and highly significant (q-value < 0.01) peaks were shortlisted from the analysis. de novo motif search was conducted by MEME-ChIP54 using the TSS proximal peaks center extended by 75 bp in both directions to determine the distribution of wtp53 and mutp53-binding sites post-treatment with reference to hg19 annotations.

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