an increasing trendp = 0.002
Differences in physiological fatigue As presented in Table 2 , although there were no differences in IL-6 (t = 0.861, p = 0.397) and TNF-α (t = 1.698, p = 0.111) levels between the 2 groups at M1, overall IL-6 levels showed an increasing trend over time (also noted in Supplementary Figure 1 ), which was statistically significant (F = 9.881, p = 0.002).