BCL-6 suppresses miR-142-3p/5p expression in SLE CD4⁺ T cells by modulating histone methylation and acetylation of the miR-142 promoter.

In addition, the expression levels of miRNA-142-3p/5p in healthy CD4 + T cells after stimulation with the anti-CD3/CD28 antibody showed a decreasing trend, but this decrease was not obvious or statistically significant. 14 In this study, we confirmed that the increased expression of BCL-6 strongly increases binding to the miR-142 promoter proximal element and the inhibition of miR-142-3p/5p expression by increasing H3K27me3 levels and reducing H3K9/K14ac levels in SLE CD4 + T cells.

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