Osthole, a Natural Plant Derivative Inhibits MRGPRX2 Induced Mast Cell Responses.

Front Immunol · 2020 · PMC7194083 · PMID 32391014

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highly significantno p-value reported

This is highly significant in situations where individuals experience both IgE-dependent and IgE-independent allergic reactions because osthole treatment will result in attenuation of mast cell activation via both MRGPRX2 and IgE receptors.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.