Selective delivery of T22-PE24-H6 to CXCR4⁺ diffuse large B-cell lymphoma cells leads to wide therapeutic index in a disseminated mouse model.

Indeed, this low BLI signal in nanoparticle-treated mice indicated a reduction of lymphoma-cell dissemination, which was already significant at day 14 after cell injection and became highly significant at days 21, 28 and 33 compared to buffer-treated animals (Figure 4 B-C).

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