Effect of Caloric Restriction on the <i>in vivo</i> Functional Properties of Aging Microglia.

Compared to middle-aged ad libitum fed male mice ( Supplementary Figure 2 ), CR3 induced a significant reduction in the frequency of spontaneous Ca 2 + transients ( p < 0.01, Mann-Whitney test) and an almost significant reduction in T-half ( p = 0.05, Mann-Whitney test), thus counteracting all aging-related changes observed in this age group (compare to Figure 3 ).

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In the lumped data, there was only a slight trend toward an increase in the fraction of active cells with age ( Figure 1B ), in contrast to data obtained in CX 3 CR1 G F P ⁣/ + mice ( 14 , 22 ).

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