Urine-based antigen detection assay for diagnosis of visceral leishmaniasis using monoclonal antibodies specific for six protein biomarkers of Leishmania infantum / Leishmania donovani.

PLoS Negl Trop Dis · 2020 · PMC7200010 · PMID 32324742

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highly significantno p-value reported

The selection criteria for these peptides included: a high MS XCorr >3.0; BLAST analysis of the peptide matching the pathogen’s biomarker having a highly significant E-value; finding two or more peptides per donor protein; found in urine samples from at least two out of ten patients; and ideally with a MW ≤30–40 kDa.

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