MSCs Contribute to the Conversion of Ly6C^high Monocytes into Ly6C^low Subsets under AMI.

Based on the different expression levels of NR4A1 identified by Western blot in the AMI heart of C57BL/6 CX3CR1-/- mice after MSC transfusion (NR4A1/GAPDH ≥ 0.2), we first found an obvious trend of myocardial fiber lysis and decrease in low-level NR4A1 group through Masson staining at day 3 after AMI (36% ± 7.5% vs. 50% ± 11%, p < 0.001) ( Figure 4(a) ), though there is no significant difference concerning thickness of the left ventricular wall at the time (data not shown).

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