Barely Significant
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Leptin signaling and the intervertebral disc: Sex dependent effects of leptin receptor deficiency and Western diet on the spine in a type 2 diabetes mouse model.

PLoS One · 2020 · PMC7202633 · PMID 32374776

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highly significantno p-value reported
Together, the highly significant changes in torsional biomechanical properties suggests leptin receptor deficiency and obesity had the largest functional changes in vertebral properties.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.