A network pharmacology-based approach to explore the effects of Chaihu Shugan powder on a non-alcoholic fatty liver rat model through nuclear receptors.

Because of the large number of screened targets, the biological mechanism covered almost all aspects of the development of NAFLD, and biological functions could also be used as screening conditions, which contribute to a more precise focus on the highly significant targets with specific biochemical functions. 4.2 The effects of CSP on NAFLD The development of NAFLD includes a wide pathological process of mechanisms involving insulin resistance, oxidative stress, endoplasmic reticulum stress, apoptosis, lipotoxicity, inflammation and the microbiome. 15 CSP is widely used in China and other East Asian countries, and the treatment spectrum involves NAFLD, 8 NASH, 9 functional dyspepsia, 16 depression, 17 atherosclerosis, 18 etc, although the specific components and targets of CSP that are most important in NAFLD are currently unclear.

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