Additionally, higher PD-L1 expression implied more advanced clinicopathological features, such as depth of invasion, histopathological stage, lymphatic metastasis, tumor metastasis, vascular invasion, tumor necrosis, and sarcomatoid features; however, tumors with high PD-L2 expression displayed only a weak trend of sarcomatoid features.
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The prevalence and prognostic and clinicopathological value of PD-L1 and PD-L2 in renal cell carcinoma patients: a systematic review and meta-analysis involving 3,389 patients.
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