CD73 blockade enhances the local and abscopal effects of radiotherapy in a murine rectal cancer model.

S 5 ). After co-culture with irradiated LuM-1 cells and rIL-2 for 12 days, splenocytes in RT and anti-CD73 mAb treated mice tended to show increased cytotoxicity against LuM-1 with marginal significance (12.8 ± 1.5% vs 7.8 ± 2.8% at E/T ratio = 20, p = 0.053, n = 3) (Fig. 4 c).

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