Syntheses and Structure-Activity Relationships in Growth Inhibition Activity against Human Cancer Cell Lines of 12 Substituted Berberine Derivatives.

Then, an obvious trend was shown that in the range of about six to eight carbon atoms; the activity increases with the elongation of the n -alkyl carbon chain of 12- N,N -di- n -alkylaminos, and when there are more than six to eight carbon atoms, the activity decreases with the elongation of the n -alkyl carbon chain.

also in 1,006 other papers