Therefore, the highly significant decline between 3 dpf and 5 dpf that was detected in WT could not be observed in mutants; the differences between 3 dpf and 5 dpf in mutants were trending albeit not statistically significant in a two-tailed unpaired t -test (loaded microglia, Fig. 2 J).
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Zebrafish disease model of human RNASET2-deficient cystic leukoencephalopathy displays abnormalities in early microglia.
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