Multigene Panel Germline Testing of 1333 Czech Patients with Ovarian Cancer.

Overrepresentation of mutations in the CHEK2 gene in OC patients in this study was marginally nonsignificant in contrast to our previous report where we identified moderately increased OC risk for CHEK2 mutation carriers [ 27 ].

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Uncorrected p values were marginally significant also for germline variants in MMP8 and FANCG in OC patients when carriers of mutations in 10 BC/OC predisposition genes significantly associating with OC risk in our study were excluded ( Table 2 ). 3.

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