highly significantp = 0.001
The mean levels of serum COMP in ng/ml, CTX-II in ng/ml, DKK1in pg/ml, TNF-αpg/ml, and IL-17 pg/ml were 5.71 ±7.04, 0.45 ±0.27, 5619.1 ±1731.4: 2.70 ±1.31, 0.23 ±0.16, 3276.96 ±1306.77, 6.4 ±2.25: 1.55 ±0.61, and 14.3 ±3.88: 5.86 ±1.09, respectively, with highly significant difference ( p = 0.001, for five biomarkers).