In multivariate CR analysis, only correlation of low CD3+ TIL with DFS or OS remained significant ( p < 0.001, Table 5 ), while low PD-L1 showed borderline significance with OS.
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CD3+T-lymphocyte infiltration is an independent prognostic factor for advanced nasopharyngeal carcinoma.
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Univariate Cox regression (CR) model analysis showed a highly significant association between low CD3+ TIL and shorter disease-free survival (DFS) whether scoring was done by the primary (CR, HR 8.5, p = < 0.001) (Table 4 ) or the secondary pathologist (CR, HR 5.8, p < 0.001) (data not shown).