Herein, we assessed the amino acid contents in the media described in the literature or analyzed internally, and identified an increasing trend of amino acid contents in the media over time that generally appears to be correlated with increased productivity (Table 1 ) (Huang et al. 2010 ; Takagi et al. 2017 ; Reinhart et al. 2015 ; Carrillo-Cocom et al. 2015 ; Pan et al. 2017 ).
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