borderline significancep = 0.05
Beyond the top eight protein networks influenced by SARS/MERS infection, our analysis shows that Transmembrane Serine Protease 2 (TMPRSS2), a protein recently proven fundamental for SARS-CoV-2 entry in the cell [ 64 ], interacts with the viral Spike protein S ( Figure 1 ), and it is downregulated by beta-coronavirus infection ( Figure 3 ), although at borderline significance and not amongst the top eight ( p = 0.05, Table S2 ).