highly significantp = 1.68 × 10 −15
Upstream regulators identified in the model included a highly significant activation of the rapamacyn-insensitive companion of mTOR (RICTOR) by Meth exposure ( p = 1.68 × 10 −15 ), and disorders assigned to cancer ( p = 3.2 × 10 −11 ), organismal injuries ( p = 3.2 × 10 −11 ), endocrine system disorders ( p = 8.83 × 10 −11 ), and metabolic disease ( p = 4.3 × 10 −9 ).