High-Throughput <i>In Vitro</i>, <i>Ex Vivo,</i> and <i>In Vivo</i> Screen of Adeno-Associated Virus Vectors Based on Physical and Functional Transduction.

An interesting trend that was observed in primary human cells, iPSCs, and several mouse organs was that a few AAV variants, such as AAV4 (multiple cell types and tissues, except the lungs), AAV5, and AAV12 (in a few targets, but especially in the case of kidney in the hFRG mouse), were very efficient at cell entry, but were unable to express the transgene at the RNA level.

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