Effect of the Most Relevant CYP3A4 and CYP3A5 Polymorphisms on the Pharmacokinetic Parameters of 10 CYP3A Substrates.

Biomedicines · 2020 · PMC7235792 · PMID 32331352

Europe PMC DOI

hedged sentence

0.0690

closest p · 1.4× alpha

0.0690

boldest claim

The sentences

almost significantlyp = 0.069so close (0.05 < p ≤ 0.1)

Subjects with CYP3A4 mutated alleles (*3, *20, *22) showed higher normalized AUC ( p = 0.099) and almost significantly lower normalized Cl ( p = 0.069), which could be a result of a diminished metabolism capacity.

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