Nebulized Poractant Alfa Reduces the Risk of Respiratory Failure at 72 Hours in Spontaneously Breathing Surfactant-Deficient Newborn Piglets.

In view of the comorbidities (airway obstruction, hypoxia, bradycardia, blood pressure fluctuation) associated with the currently approved way of administering surfactant (intubation, surfactant bolus and mechanical ventilation), in neonatal ICUs, there has been a notable trend toward a greater use of noninvasive ventilation such as nCPAP, combined with InSurE or less invasive surfactant administration techniques ( 1 , 2 , 25 ).

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