highly significantp ≤ 0.003
In particular, the differences between early-NASH and advanced-NASH, and between steatosis grade 0,1 and steatosis grade 2,3 were more significant than between the other groups; the former exhibited the most number of altered pathways and the latter exhibited the most number of pathways that were highly significant ( p ≤ 0.003) ( Table S3, Figure S1 ).