Growth study under combined effects of temperature, pH and salinity and transcriptome analysis revealed adaptations of Aspergillus terreus NTOU4989 to the extreme conditions at Kueishan Island Hydrothermal Vent Field, Taiwan.

In 30‰ salinity, growth rates were generally higher in pH 9 with a decreasing trend with increasing temperatures.

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Within each tested pH, there was a slightly increasing trend in growth rate when the incubation temperature increased from 15 °C to 37 °C.

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