Indeed, statistical analysis showed a highly significant difference between the number of cells with ~4N chromosome number and cells with extra centrosomes at day 12 for both DLD-1 and RPE-1 p53 -/- cells (two-sided Chi square test, p<0.0001 for both cell lines), indicating that a large fraction of the tetraploid cells that are present 12 days post-cytokinesis failure have lost their extra centrosomes.
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Asymmetric clustering of centrosomes defines the early evolution of tetraploid cells.
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