Intranasal Delivery of miR-155-5p Antagomir Alleviates Acute Seizures Likely by Inhibiting Hippocampal Inflammation.

Keywords intranasal delivery epilepsy pentetrazol inflammatory response miR-155-5p As shown in Figure 1B , via statistical analysis, the relative miR-155-5p levels increased to 1.42 and 1.59-fold in the pilocarpine- and pentetrazol-induced models, in comparison with the levels in the control group, but the latter model seemed to be a better model for this study due to higher fold change along with smaller magnitude with an increasing trend of miR-155-5p levels, indicating that the model is fit for exploring the effects of miR-155-5p antagomir on epileptic seizures.

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