Study on myelin injury of AD mice treated with Shenzhiling oral liquid in the PI3K/Akt-mTOR pathway.

Int J Immunopathol Pharmacol · 2020 · PMC7262987 · PMID 32462951

Europe PMC DOI

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an increasing trendno p-value reported

After 3 months of treatment using SZL, all of the MBP, PSD95 content and the PI3K/Akt/mTOR pathway-related proteins of mice showed an increasing trend, consistent with that of the D group.

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a decreasing trendno p-value reported

Meanwhile, the expression of PI3K, Akt, mTOR, p-PI3K, p-Akt and p-mTOR in 6-month-old APPswe/PS1dE9 transgenic mice showed a decreasing trend, highlighting the relationship between the PI3K/Akt–mTOR pathway and cognitive disorder.

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