REDD1 loss reprograms lipid metabolism to drive progression of <i>RAS</i> mutant tumors.

The most highly significant gene expression differences between KRMEFs and KMEFs were evident under both normoxia and hypoxia, where Gene Set Enrichment Analysis (GSEA) revealed profound suppression of genes regulating cholesterol and fatty acid synthesis (FASyn) as the top differentially expressed signature ( Fig. 2 A; Supplemental Fig.

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