Sex-biased genetic programs in liver metabolism and liver fibrosis are controlled by EZH1 and EZH2.

PLoS Genet · 2020 · PMC7263639 · PMID 32428001

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highly significantno p-value reported

Upstream regulators of Ezh1/Ezh2-dependent genes Upstream Regulator Analysis identified STAT5b as the most significant upstream regulator of the set of female-biased genes de-repressed in E1/E2-KO male liver (p-value of overlap: 2.19E-23), i.e., there is a highly significant enrichment for gene targets of STAT5b ( S4A Table ).

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