hCMEC cultures incubated with TNFα showed a barely significant induction of IFNβ (Fig. 7O ). hCMEC cultures treated with both E. coli EV36 and phage K1F exhibited responses characterised by a greater variation within and between experiments of induced expression of IFNβ yielding no statistically significant differences between treatments.
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Bacteriophage K1F targets Escherichia coli K1 in cerebral endothelial cells and influences the barrier function.
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