extremely significantP = 0.001
In addition, pairwise ANOSIM analyses suggested that there were extremely significant differences between the CN and LC groups (global R = 0.4905, P = 0.001), between the CN and HC groups (global R = 0.3245, P = 0.001), and between the LC and HC groups (global R = 0.2366, P = 0.008) ( Table 5 ).