At the protein level, surface CD11b expression was reduced in both ATRA‐treated knockdown clones (* P = 0.0434 in shISG15_319 clone), but did not achieve significance in the shISG15_352 knockdown clone (Fig. 5 C).
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Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA-induced differentiation of leukemic cells.
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