Comparison of four algorithms on establishing continuous reference intervals for pediatric analytes with age-dependent trend.

BMC Med Res Methodol · 2020 · PMC7268336 · PMID 32487062

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a decreasing trendno p-value reported

However, boys’ and girls’ ALP levels showed a decreasing trend in the first 4 years of life, but the levels then increased until puberty.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.