Fosmanogepix (APX001) Is Effective in the Treatment of Pulmonary Murine Mucormycosis Due to Rhizopus arrhizus.

Doses of fosmanogepix in mice that achieved clinically relevant exposures (78 mg/kg and 104 mg/kg) demonstrated significantly improved survival compared to the placebo control ( P < 0.01 by log rank test), whereas the low dose of 52 mg/kg fosmanogepix, although numerically better than placebo control, did not achieve significance ( P = 0.07) ( Fig. 1A ).

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