A stress-responsive enhancer induces dynamic drug resistance in acute myeloid leukemia.

J Clin Invest · 2020 · PMC7269587 · PMID 31770110

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highly significantno p-value reported

Consistent with ATF4 being a core driver of the upregulated ISR-like transcriptional program, GSEA demonstrated highly significant enrichment for ATF4 target genes among genes upregulated in daunorubicin-resistant versus sensitive K562 cells ( Figure 2E ).

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