The transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice.

Nat Commun · 2020 · PMC7270082 · PMID 32493987

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highly significantno p-value reported

When we used gene set enrichment analysis to compare differentially expressed genes in E6.5 Blimp1 mutants with predicted progesterone and oestrogen responsive genes (based on proximal PR and Esr1 binding) we observed a highly significant correlation (FDR q -value > 0.0001) between downregulated genes in Blimp1 mutant decidua and progesterone receptor target genes (Fig. 4d ).

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