Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model.

PLoS Genet · 2020 · PMC7272101 · PMID 32427991

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highly significantno p-value reported

Because z-scores are so noisy, it is possible for a typed SNP with a highly significant p-values in one GWAS to completely fail to reach significance in a subsequent GWAS, and for these outcomes to be statistically consistent.

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