Identification of SARS-CoV-2 Vaccine Epitopes Predicted to Induce Long-Term Population-Scale Immunity.

Although the epitopes presented here are based on computational predictions (which do not account for the multiple steps involved in antigen processing and presentation), our previous validation of peptide presentation using liquid chromatography-tandem mass spectrometry (LC-MS/MS) of peptides eluted from MHC across multiple tumors showed highly significant concordance with predicted population-scale presentation. 17 Although we expect a significant fraction of predicted antigens to be presented on MHC, binding predictions alone do not determine which antigens will elicit an immunodominant response.

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