FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences.

Overall, we observed a modest (R = 0.21) but highly significant (p=1e-37) correlation between the mislocalization of genes in the CAD knockout system and the mislocalization of their human orthologs in the FXS iPS system ( Figure 3—figure supplement 5 , Supplementary file 1b ).

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